abstract：:Current antipsychotic drugs (APDs) act on D2 receptors, and preclinical studies demonstrate that repeated D2 antagonist administration downregulates spontaneously active DA neurons by producing overexcitation-induced inactivation of firing (depolarization block). Animal models of schizophrenia based on the gestational...

journal_title：Neuropharmacology

authors： Sonnenschein SF,Grace AA

更新日期：2020-02-01 00:00:00

abstract：:Remifentanil is commonly used clinically for perioperative pain relief, but it may induce postoperative hyperalgesia. Low doses of ketamine have remained a common choice in clinical practice, but the mechanisms of ketamine have not yet been fully elucidated. In this study, we examined the possible effects of ketamine ...

journal_title：Neuropharmacology

authors： Qi F,Liu T,Zhang X,Gao X,Li Z,Chen L,Lin C,Wang L,Wang ZJ,Tang H,Chen Z

更新日期：2020-01-01 00:00:00

abstract：:Cocaine induces neuroinflammatory response and interleukin-1 beta (IL1β) is suggested a final effector for many cocaine-induced inflammatory signals. Recently, the chemokine fractalkine (CX3CL1) has been reported to regulate hippocampus-dependent neuroinflammation and synaptic plasticity via CX3C-receptor 1 (CX3CR1), ...

journal_title：Neuropharmacology

authors： Montesinos J,Castilla-Ortega E,Sánchez-Marín L,Montagud-Romero S,Araos P,Pedraz M,Porras-Perales Ó,García-Marchena N,Serrano A,Suárez J,Baixeras E,Rodríguez-Arias M,Santín LJ,Miñarro J,Guerri C,Rodríguez de Fonseca F,Pavó

更新日期：2020-01-01 00:00:00

abstract：:Neural uptake of glutamate is executed by the structurally related members of the SLC1A family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2. These plasma membrane proteins ensure supply of glutamate, aspartate and some neutral amino acids, including glutamine and cysteine, for synthetic,...

journal_title：Neuropharmacology

authors： Gegelashvili G,Bjerrum OJ

更新日期：2019-12-15 00:00:00

abstract：:ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the pathophysiology of various neurological diseases such as epilepsy, Alzheimer's disease and stroke. GABA transporters (GATs) facilitate the termi...

journal_title：Neuropharmacology

authors： Kickinger S,Hellsberg E,Frølund B,Schousboe A,Ecker GF,Wellendorph P

更新日期：2019-12-15 00:00:00

abstract：:Amphetamine (AMPH) acts as a substrate of the dopamine transporter (DAT) and causes a dramatic increase in extracellular dopamine (DA). Upon entering DA neurons, AMPH promotes DA efflux via DAT through a mechanism implicating depletion of DA from vesicular stores, activation of kinase pathways and transporter phosphor...

journal_title：Neuropharmacology

authors： Runegaard AH,Dencker D,Wörtwein G,Gether U

更新日期：2019-12-15 00:00:00

abstract：:Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist a...

journal_title：Neuropharmacology

authors： Shueb SS,Erb SJ,Lunzer MM,Speltz R,Harding-Rose C,Akgün E,Simone DA,Portoghese PS

更新日期：2019-12-01 00:00:00

abstract：:Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have been implicated in the release of dopamine from the ventral tegmental area to the nAc in the presence of ethanol. One of the major types of neurons in the nAc ...

journal_title：Neuropharmacology

authors： Gallegos S,Muñoz B,Araya A,Aguayo LG

更新日期：2019-12-01 00:00:00

abstract：:Biogenic monoamines are involved in the regulation of various processes in both neural and non-neural cells during development. The present study aimed to identify the regulatory effects of serotonin (5-HT) and its precursors (l-tryptophan and 5-hydroxytryptophan, 5-HTP) on proliferation and cell death in mouse embryo...

journal_title：Neuropharmacology

authors： Gordeeva O,Safandeev V

更新日期：2019-11-25 00:00:00

abstract：:Rodents emit ultrasonic vocalizations (USVs) to communicate the presence of positive or negative emotional states and to coordinate social interactions. On this basis, USVs are increasingly being used as a behavioral readout in rodent studies of affect, motivation and social behavior. Notably, several investigations h...

journal_title：Neuropharmacology

authors： Simola N,Granon S

更新日期：2019-11-15 00:00:00

abstract：:One proposed factor contributing to the increased frequency of opioid overdose deaths is the emergence of novel synthetic opioids, including illicit fentanyl and fentanyl analogues. A treatment strategy currently under development to address the ongoing opioid crisis is immunopharmacotherapies or opioid-targeted vacci...

journal_title：Neuropharmacology

authors： Tenney RD,Blake S,Bremer PT,Zhou B,Hwang CS,Poklis JL,Janda KD,Banks ML

更新日期：2019-11-01 00:00:00

abstract：:The homotrimeric P2X3 receptor, one of the seven members of the ATP-gated P2X receptor family, plays a crucial role in sensory neurotransmission. P2X3 receptor antagonists have been identified as promising drugs to treat chronic cough and are suggested to offer pain relief in chronic pain such as neuropathic pain. Her...

journal_title：Neuropharmacology

authors： Obrecht AS,Urban N,Schaefer M,Röse A,Kless A,Meents JE,Lampert A,Abdelrahman A,Müller CE,Schmalzing G,Hausmann R

更新日期：2019-11-01 00:00:00

abstract：:Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and has recently been shown effective for the treatment of childhood seizures caused by Dravet and Lennox-Gastaut syndromes. Given evidence for activity to mitigate effects of CNS insu...

journal_title：Neuropharmacology

authors： Alalawi A,Dodu JC,Woolley-Roberts M,Brodie J,Di Marzo V,Soderstrom K

更新日期：2019-11-01 00:00:00

abstract：:Nicotine improves endotoxic manifestations of hypotension and cardiac autonomic dysfunction in rats. Here, we test the hypothesis that brainstem antiinflammatory pathways of α7/α4β2 nicotinic acetylcholine receptors (nAChRs) modulate endotoxic cardiovascular derangements. Pharmacologic and molecular studies were perfo...

journal_title：Neuropharmacology

authors： Sallam MY,El-Gowilly SM,Fouda MA,Abd-Alhaseeb MM,El-Mas MM

更新日期：2019-10-01 00:00:00

abstract：:Aggression is a common symptom of several human psychiatric disorders. However, the drugs available to treat aggression are non-specific and can have unwanted side effects. The zebrafish is an ideal model for behavioural pharmacology. They are small, aggression can be measured reliably, and drugs can be applied by imm...

journal_title：Neuropharmacology

authors： Norton WHJ

更新日期：2019-09-15 00:00:00

abstract：:Palatability driven feeding and voluntary physical activity are mediated by and influence similar neural mechanisms, notably through the actions of opioids within the nucleus accumbens. Recent studies suggest that access to a voluntary running wheel results in sex dependent behavioral and physiological adaptations rel...

journal_title：Neuropharmacology

authors： Lee JR,Tapia MA,Weise VN,Bathe EL,Vieira-Potter VJ,Booth FW,Will MJ

更新日期：2019-09-01 00:00:00

abstract：:The obesity epidemic is one of the biggest health challenges globally and rates have tripled since 1975. Overeating is the largest determinant of obesity, yet little is understood of the neural mechanisms underlying why individuals consume food regardless of satiety. The lateral hypothalamic (LH) input to the ventral ...

journal_title：Neuropharmacology

authors： Godfrey N,Borgland SL

更新日期：2019-08-01 00:00:00

abstract：:Orexins are neuropeptides that are exclusively produced by hypothalamic neurons, which project throughout the entire brain. Orexin, also known as hypocretins, were initially identified to play a fundamental role in food intake, arousal and the regulation of sleep and wakefulness. Recent studies identified orexins to b...

journal_title：Neuropharmacology

authors： Sargin D

更新日期：2019-08-01 00:00:00

abstract：:Consistent experimental evidence supports an important role of the glutamatergic system in the etiopathogenesis of schizophrenia. Numerous studies propose that blockade of the NMDA receptor by its antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in ...

journal_title：Neuropharmacology

authors： Zoupa E,Gravanis A,Pitsikas N

更新日期：2019-06-01 00:00:00

abstract：:Depression is a leading cause of mortality and morbidity. Selective serotonin reuptake inhibitors, such as fluoxetine, are the most commonly prescribed antidepressant medication. SSRIs produce their therapeutic effects by elevating extracellular concentrations of serotonin. Although this elevation occurs rapidly, ther...

journal_title：Neuropharmacology

authors： Van Dyke AM,Francis TC,Chen H,Bailey AM,Thompson SM

更新日期：2019-05-15 00:00:00

abstract：:Elimination of brain cholesterol occurs in the form of 24S-hydroxycholesterol (24S-HCh) that may modulate physiological processes outside the brain. Here, using microelectrode recording of postsynaptic responses (end-plate potentials, EPPs) and fluorescent marker (FM1-43) for endo-exocytosis we studied the effects of ...

journal_title：Neuropharmacology

authors： Mukhutdinova KA,Kasimov MR,Zakyrjanova GF,Gumerova MR,Petrov AM

更新日期：2019-05-15 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:Methylazoxymethanol (MAM)-treated pregnant rat at gestation day (GD) 17 has been shown to be a valuable developmental animal model for schizophrenia. Yet, this model remains to be established in mice. In the present study, we examined behavioral, cytoarchitectural, and neurochemical changes in the offspring of MAM-tre...

journal_title：Neuropharmacology

authors： Takahashi K,Nakagawasai O,Sakuma W,Nemoto W,Odaira T,Lin JR,Onogi H,Srivastava LK,Tan-No K

更新日期：2019-05-15 00:00:00

abstract：:Limited information exists on the link between purinergic class P2X7 receptors (P2X7Rs) and calcium ion channels in epilepsy; no data has been reported regarding the interaction between P2X7Rs and T-type calcium ion channels in epilepsy. Thus, this study is an evaluation of the role that T-type calcium ion channels pl...

journal_title：Neuropharmacology

authors： Arslan G,Avci B,Kocacan SE,Rzayev E,Ayyildiz M,Agar E

更新日期：2019-05-01 00:00:00

abstract：:While evidence indicates that sigma-1 receptors (Sig-1Rs) play an important role in the induction of peripheral neuropathic pain, there is limited understanding of the role that the neurosteroidogenic enzymes, which produce Sig-1R endogenous ligands, play during the development of neuropathic pain. We examined whether...

journal_title：Neuropharmacology

authors： Choi SR,Roh DH,Yoon SY,Choi HS,Kang SY,Han HJ,Beitz AJ,Lee JH

更新日期：2019-05-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a serious public health problem that results in tremendous social, legal and medical costs to society. Unlike other addictive drugs, there is no specific molecular target for ethanol (EtOH). Here, we report a novel molecular target that mediates EtOH effects at concentrations below those ...

journal_title：Neuropharmacology

authors： Gao F,Chen D,Ma X,Sudweeks S,Yorgason JT,Gao M,Turner D,Eaton JB,McIntosh JM,Lukas RJ,Whiteaker P,Chang Y,Steffensen SC,Wu J

更新日期：2019-05-01 00:00:00

abstract：:Ketogenesis is a metabolic process wherein ketone bodies are produced from the breakdown of fatty acids. In humans, fatty acid catabolism results in the production of acetyl-CoA which can then be used to synthesize three ketone bodies: acetoacetate, acetone, and β-hydroxybutyrate. Ketogenesis occurs at a higher rate i...

journal_title：Neuropharmacology

authors： Pflanz NC,Daszkowski AW,James KA,Mihic SJ

更新日期：2019-04-01 00:00:00

abstract：:Adenosine A2a receptors (A2aRs) are highly and selectively expressed in D2-medium spiny neurons (D2-MSNs) that also express a high level of dopamine D2 receptors (D2Rs). However, it was not established how A2aR activity affects D2-MSN excitability, let alone the ion channels involved. We have performed two sets of exp...

journal_title：Neuropharmacology

authors： Wang Q,Zhou FM

更新日期：2019-04-01 00:00:00

abstract：:The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although the underlying mechanisms and/or therapeutic target are not yet clear. In this study, we investigated the involvement of the glutamatergic neuronal system in the ...

journal_title：Neuropharmacology

authors： Hasegawa S,Yoshimi A,Mouri A,Uchida Y,Hida H,Mishina M,Yamada K,Ozaki N,Nabeshima T,Noda Y

更新日期：2019-04-01 00:00:00

abstract：:The Forkhead Box G1 (FOXG1) gene encodes a transcription factor with an essential role in mammalian telencephalon development. FOXG1-related disorders, caused by deletions, intragenic mutations or duplications, are usually associated with severe intellectual disability, autistic features, and, in 87% of subjects, epil...

journal_title：Neuropharmacology

authors： Testa G,Mainardi M,Olimpico F,Pancrazi L,Cattaneo A,Caleo M,Costa M

更新日期：2019-04-01 00:00:00

abstract：:A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

journal_title：Neuropharmacology

authors： Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

更新日期：2019-03-01 00:00:00

abstract：:A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan has been the co-occurrence of blast-related mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI might coexist due to additive effects of independent psychological and physical traum...

journal_title：Neuropharmacology

authors： Perez-Garcia G,Gama Sosa MA,De Gasperi R,Tschiffely AE,McCarron RM,Hof PR,Gandy S,Ahlers ST,Elder GA

更新日期：2019-02-01 00:00:00

abstract：:Adolescence is a critical period for postnatal brain maturation and a time during which there is increased susceptibility to developing emotional and cognitive-related disorders. Exercise during adulthood has been shown to increase hippocampal plasticity and enhance cognition. However, the impact of exercise initiated...

journal_title：Neuropharmacology

authors： O'Leary JD,Hoban AE,Cryan JF,O'Leary OF,Nolan YM

更新日期：2019-02-01 00:00:00

abstract：:Gene-environment interactions drive experience-dependent changes in the brain that alter cognition, emotion and behaviour. Positive engagement with the environment, through novel experience and physical activity, can improve brain function, although the mechanisms mediating such experience-dependent plasticity remain ...

journal_title：Neuropharmacology

authors： Rogers J,Renoir T,Hannan AJ

更新日期：2019-02-01 00:00:00

abstract：:Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality in children. Experimental and clinical studies demonstrate that the developmental age, the type of injury (diffuse vs. focal) and sex may play important roles in the response of the developing brain to a traumatic injur...

journal_title：Neuropharmacology

authors： Huh JW,Raghupathi R

更新日期：2019-02-01 00:00:00

abstract：:Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the profile of THC could be improved by co-administering it with the first-...

journal_title：Neuropharmacology

authors： Atwal N,Casey SL,Mitchell VA,Vaughan CW

更新日期：2019-01-01 00:00:00

abstract：:Human genetic variation in the gene CACNA1C, which codes for the alpha-1c subunit of Cav1.2 L-type calcium channels (LTCCs), has been broadly associated with enhanced risk for neuropsychiatric disorders including major depression, bipolar and schizophrenia. Little is known about the specific neural circuits through wh...

journal_title：Neuropharmacology

authors： Ehlinger DG,Commons KG

更新日期：2019-01-01 00:00:00

abstract：:miR-132 and miR-212 are structurally-related microRNAs that are expressed from the same non-coding transcript. Accumulating evidence has shown that the dysregulation of these microRNAs contributes to aberrant neuronal plasticity and gene expression in the mammalian brain. Consistent with this, altered expression of mi...

journal_title：Neuropharmacology

authors： Aten S,Page CE,Kalidindi A,Wheaton K,Niraula A,Godbout JP,Hoyt KR,Obrietan K

更新日期：2019-01-01 00:00:00

abstract：:Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression of various cancers. However, the molecular mechanism and pathological role of bradykinin recept...

journal_title：Neuropharmacology

authors： Liu YS,Hsu JW,Lin HY,Lai SW,Huang BR,Tsai CF,Lu DY

更新日期：2019-01-01 00:00:00

abstract：:Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause CDKL5 Deficiency Disorder (CDD), a rare neurodevelopmental syndrome characterized by severe behavioural and physiological symptoms. No cure is available for CDD. CDKL5 is a kinase that is abundantly expressed in the brain and plays a critical ...

journal_title：Neuropharmacology

authors： Vigli D,Rusconi L,Valenti D,La Montanara P,Cosentino L,Lacivita E,Leopoldo M,Amendola E,Gross C,Landsberger N,Laviola G,Kilstrup-Nielsen C,Vacca RA,De Filippis B

更新日期：2019-01-01 00:00:00